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FABIAN 2008
Biopharma,
Biosimilar, Biogeneric? Bioanalysis!
6 November 2008, UMCG, Groningen
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Poster |
Abstract
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CHARACTERIZATION OF IMPURITIES AND
MODIFICATIONS IN PROTEIN PRODUCTS USING LIQUID CHROMATOGRAPHY AND DATA
INDEPENDENT ACQUISITION TANDEM MASS SPECTROMETRY
Mike van Oosterhout, Waters Chromatography
Etten-leur, NL
Hongwei Xie, Martin Gilar, John C. Gebler Waters Corporation, Milford, MA USA
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08P01
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AN AUTOMATED LC/MS DATA ANALYSIS USING BIOPHARMALYNX: A CASE STUDY FOR
CHARACTERISATION OF THERAPEUTIC INTERFERON PROTEIN
Mike van Oosterhout, Waters Chromatography, Etten-leur, NL
Joomi Ahn, Ying Qing Yu, Martin Gilar, John Gebler Waters Corporation, Milford,
MA USA
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08P02
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CE-ToF-MS systems using non-covalent
multi-layer coated capillaries for the analysis of pharmaceutical proteins
Rob Haselberg*,
Gerhardus J. de Jong and Govert W. Somsen
Department of Biomedical Analysis, Utrecht University, P.O. Box 80082, 3508 TB
Utrecht, the Netherlands
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08P03
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In vivo microdialysis in rats:
LC-MS/MS analysis of microdialysis samples
Brigitte Buscher, Ria Brust-van Schaik, Inge
van Schöll, Astrid Capello and Florence Salmon
TNO Quality of life, Utrechtseweg 48, 3700 AJ Zeist, The Netherlands
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08P04
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NEW APPLICATIONS OF QTRAP® AND TRIPLE QUADRUPOLE SYSTEMS IN PHARMACEUTICAL
ANALYSIS
Applied Biosystems|MDS Analytical Technologies
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08P05
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EMPLOYING HIGHER RESOLUTION TO OBTAIN BETTER SELECTIVITY FOR QUANTITATION
EXPERIMENTS ON A TRIPLE- QUADRUPOLE INSTRUMENT PLATFORM (API 5000TM LC/MS
SYSTEM)
Anthony J. Romanelli, Jeffrey D. Miller, Xavier J.
Misonne,
Applied Biosystems, Framingham, MA, USA
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08P06
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A HIGHLY AUTOMATED WORKFLOW FOR FAST AND COMPREHENSIVE IDENTIFICATION OF
IMPURITIES AND DEGRADATION PRODUCTS IN PHARMACEUTICAL PRODUCTS USING LC/MS/MS.
John Gibbons1, Nicolas Rupcich2 and David Duncan2,
1. Applied Biosystems / MDS Analytical Technologies, Concord, Ontario, Canada,
2. Genpharm Inc., Etobicoke, Ontario, Canada
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08P07
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HARDWARE AND SOFTWARE DESIGN STRATEGIES FOR THE RAPID DETERMINATION OF
OPTIMAL QUANTITATIVE MS/MS CONDITIONS
April L. Smith1; Anthony J. Romanelli1;
Elliott Jones1; John Janiszewski2; Hua-fen Liu1;
Steve Ainley3; Richard Schneider2; Kevin Shirey3;
Eva Duchoslav1; Loren Olson1
1. Applied Biosystems, Framingham, MA and Foster City, CA;
2. Pfizer Inc., Westerly, RI;
3. Sound Analytics, East Lyme, CT
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08P08
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ACCELERATED LC/MS/MS FOR THE QUANTITATION AND CONFIRMATION OF PESTICIDES IN
FOOD AND WATER SAMPLES
André Schreiber1, Doina Caraiman1,
Nadia Pace1, Tim Hoffman1, Byron Kieser1 and CJ
Baker2
1. Applied Biosystems/MDS Analytical Technologies Concord, ON (Canada),
2. University of Calgary, Calgary, AL (Canada)
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08P09
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EFFICIENT PEPTIDE PURIFICATION BY
HPLC, EFFECT OF PORE SIZE, PARTICLE SIZE AND CHEMISTRY.
Gezinus Grooten
Aurora Borealis Control BV, Schoonebeek, The Netherlands
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08P10
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YMC-BIOPRO, POROUS AND NONPOROUS IEX
COLUMNS.
Gezinus Grooten
Aurora Borealis Control BV, Schoonebeek, The Netherlands
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08P11
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LAMP-BASED NATIVE FLUORESCENCE DETECTION OF PHARMACEUTICAL
PROTEINS IN CAPILLARY ELECTROPHORESIS
B.J. de Kort*, D.Č. Radenović, G.J. De
Jong, G.W. Somsen
Department of Biomedical Analysis, Utrecht University, P.O. Box 80082, 3508 TB
Utrecht, the Netherlands
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08P12
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METHOD VALIDATION APPROACH FOR THE DETERMINATION OF ANTIBODY
RESPONSE TO BIOPHARMACEUTICALS
Marcel van der Linden, Ole Lagatie,
Harry Verdonk and Jan Dankers
Eurofins Medinet B.V., Department of Specialized Biomolecules, Bergschot 71,
4817 PA Breda, The Netherlands
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08P13
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DEVELOPMENT OF AN AUTOMATED SPR-IMER-LC-MS/MS PLATFORM FOR
ISOLATION, QUANTIFICATION AND IDENTIFICATION OF PROTEINS FROM PLASMA
E.C.A. Stigter*, G.J. de Jong,
W.P. van Bennekom
Utrecht University, Faculty of Sciences, Department of Pharmaceutical Sciences
(Biomedical Analysis), Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
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08P14
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ELISA WITH ICP-MS DETECTION AS A SELECTIVE DETECTION TECHNIQUE
FOR BIOMARKER ASSAYS
Simone Hof, Monique Putman and
Jaap
Wieling
Xendo Drug Development Services, P.O. Box 137, 9700 AC, The Netherlands
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08P15
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STATISTICAL EVALUATION OF THE BENEFIT OF COMBINED USE OF
ACCURATE MASS AND ISOTOPIC PATTERN
Marcus Macht1; Petra Decker1;
Aiko Barsch1; Ilmari Krebs1 and Rob van der Heijden2
1 Bruker Daltonik, Bremen, Germany
2 Bruker Daltonics BV, Wormer, the Netherlands
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08P16
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SOFTWARE-SUPPORTED TOP-DOWN PROTEIN SEQUENCE CHARACTERIZATION
AND ASSIGNMENT OF TERMINI
Detlev Suckau1, Lars Vorwerg1,
Anja Resemann1 and Rob van der Heijden2
1 Bruker Daltonik GmbH, Bremen, Germany
2 Bruker Daltonics BV, Wormer, The Netherlands
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08P17
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ADVANCES IN THE OPTIMIZATION OF A MICRO-FLOW HPLC (LC-MS)
SYSTEM
Rein Reitsma
Separations Analytical Instruments, The Netherlands
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08P18
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INTEGRATED BIOPHARMACEUTICAL DEVELOPMENT: NEW CHALLENGES TO
EXPIDITE THE PROOF-OF-CONCEPT STAGE AND TIME TO MARKET
Izaak den Daas, Johan Wemer, Ineke Jonker, Thijs van
Iersel, Ard Tijsterman and
Jaap
Wieling
Xendo Integrated Biopharmaceutical Development, Hanzeplein 1, Entrance 53, 9713
GZ Groningen, The Netherlands
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08P19
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(PRE)CLINICAL IMMUNOGENICITY ASSAY DEVELOPMENT
Hans Mocking and Cees Koopal
TNO Quality of Life, Dept. of Analytical Research, Utrechtseweg 48, 3704 HE
Zeist, The Netherlands.
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08P20
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CIEF–MALDI-TOF-MS FOR THE ANALYSIS OF (BIOPHARMACEUTICAL) PROTEINS
L.H.H. Silvertand, J. Sastre Toraño, G.J. de Jong,
W.P. van Bennekom
Biomedical Analysis, Pharmaceutical Analysis, University of Utrecht, P.O. Box
80082, 3508 TB Utrecht, The Netherlands
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08P21
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