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FABIAN 2007

De waarde van biomedische analyse:
een wereld van verschil


6 November, Janssen Pharmaceutica, Beerse

 

07P01 Impact on Ion Suppression by Eliminating Phospholipid Interferences Using a Generic TurboFlow® Method
François A. Espourteille; Catherine LaFontaine (Thermo Fisher Scientific, Franklin, MA, USA)
07P02 A Systematic Approach To Reducing Matrix Effects In Bioanalytical Studies
Uwe D. Neue and Patrick D. McDonald (Waters Corporation)
07P03 How to determine matrix effects and extraction recovery in online solid-phase extraction – liquid chromatography – mass spectrometry
Alex Berhitu, Emile Koster (Spark System Solutions B.V., P.O. Box 388, 7800 AJ Emmen)
07P04 A systematic online SPE-LC-MS/MS method development strategy for the analysis of biological samples
Rob Castien, Martin Sibum, Emile Koster (Spark System Solutions B.V., P.O. Box 388, 7800 AJ Emmen)
07P05 Accurate mass and isotopic pattern based routine drug screening in horse urine using liquid chromatography/time-of-flight mass spectrometry.
Matthias Pelzing1; Geoff Beresford2; Chris Hendrix3; Rob Howitt1; Ian Sanders4 (1. Bruker Biosiences Pty Ltd, Brunswick, Australia, 2. New Zealand Racing Laboratory Services, Auckland, New Zealand, 3. Bruker Daltonics BVBA, Brussels, Belgium, 4. Bruker Daltonik GmbH, Bremen, Germany)
07P06 Metabolic Profiling of Amino Acids in Urine using CE-ESI-TOF-MS
Oleg Mayboroda2; Rico Derks2; Gabriela Zurek1; Matthias Pelzing3; Christian Neusuess4;
Chris Hendrix5; Andree Deelder2 (1. Bruker Daltonik GmbH, Bremen, Germany, 2. LUMC, Leiden, Netherlands, 3. Bruker Daltonics Australia, Melbourne, Australia, 4. HTW Aalen, Aalen, Germany, 5. Bruker Daltonics BVBA, Brussels, Belgium)
07P07 Detailed Investigation of the Fragmentation of aminopyridinyl-sulfanyl-imidazole-based MAPKinase Inhibitors using accurate MS(n) and isotopic pattern data
Holger Scheible1; Ilmari Krebs2; Sebastian Goetz2; Gabriela Zurek2; Wolfgang Albrecht3;
Chris Hendrix4; Christoph Gleiter1; Stefan Laufer1; Bernd Kammerer1 (1. University of Tuebingen, Tuebingen, Germany, 2. Bruker Daltonik GmbH, Bremen, Germany, 3. Merckle GmbH, Ulm, Germany, 4. Bruker Daltonics BVBA, Brussels, Belgium)
07P08 Determination of loratadine in dog plasma by high-performance liquid chromatography with fluorescence detection
J. De Smet1, W. Goeteyn1, J.-P. Remon2, and J.F.P. Van Bocxlaer1 (1. Laboratory of Medical Biochemistry and Clinical Analysis, Ghent University, Harelbekestraat 72, B-9000 Gent, Belgium, 2. Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, B-9000 Gent, Belgium)
07P09 Quantitative Analysis on a Novel MALDI Triple Quadrupole Platform
Jean-François Alary, George Scott, Feng Zhong, Jay Corr (Applied Biosystems/MDS Sciex, 71 Four Valley Drive, Concord, Ontario, Canada, L4K 4V8)
07P10 FlashQuant™ Workstation – Bringing Speed to Standard ADME Assays
(Applied Biosystems/MDS Sciex, 71 Four Valley Drive, Concord, Ontario, Canada, L4K 4V8)
07P11 Evaluation of MALDI Triple Quadrupole Mass Spectrometry for High Throughput Drug-Drug Interaction Screening
Feng Zhong, Hesham Ghobarah, Daniel Lebre, George Scott, Gary Impey and Jay Corr (Applied Biosystems/MDS Sciex, 71 Four Valley Drive, Concord, Ontario, Canada, L4K 4V8)
07P12 High Throughput Automated LC/MS/MS Strategies for ADME Workflows: Software Based Automation for Method Development and Data Collection.
Loren Y Olson1, Anthony J Romanelli1, Christopher Borton1, Wen-Chen Hsu2, Pengdeth Lim2, Huafen Liu1, May Young2, Jane Huang2, Peadar Cremin3, Mark Warren3, Ying Bao3, Manping Ji3, Kerry Koller3, Quincey Wu3 and Elliott B Jones1 (1. Applied Biosystems, 850 Lincoln Center Drive, Foster City, CA 94404, 2. Roche, Palo Alto, CA, USA, 3. Xenoport Inc., Santa Clara, CA, USA)
07P13 Quantitative determination of glycopyrrolate in human plasma by liquid chromatography – electrospray ionization mass spectrometry
R. t’Kindt, M. Storme, W. Goeteyn, J. Van Bocxlaer (Laboratory of Medical Biochemistry and Clinical Analysis, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium)
07P14 Biomarkers: from diagnostic tool to GLP validated efficacy determinations
Jan Dankers, Ole Lagatie, Marcel van der Linden, Jean-Paul Boon (Eurofins Medinet, Bergschot 71, 4817PA, Breda, The Netherlands)
07P15 Evaluation of a novel phenotyping cocktail for phenotyping three human cytochromes P450 iso-enzymes CYP2D6, CYP2C19 and CYP3A4 in healthy volunteers.
M.P. van Iersel, T. de Boer, J. B. Hak, J. Wieling, R. S. Schwietert, I. den Daas and J. Wemer. (Xendo Drug Development BV, Hanzeplein 1, 9713 GZ Groningen, The Netherlands)
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18-Mar-08